Yitshak Zohar

Professor of Aerospace and Mechanical Engineering
Director, Integrated Microsystem Laboratory
Professor of Biomedical Engineering
Professor, BIO5 Institute
Yitshak Zohar

AME N737

520.626.8093
zohar@arizona.edu

Yitshak Zohar received BS and MS degrees in aeronautical engineering from the Technion—Israel Institute of Technology, Haifa, Israel, in 1981 and 1984, respectively, and a PhD degree in aerospace engineering from the University of Southern California (USC), Los Angeles, in 1990. He was a research associate at USC from 1990 to 1992, working on microelectromechanical systems research projects. He was also with the Department of Mechanical Engineering of Hong Kong University of Science and Technology, Hong Kong, as one of the founding faculty members in 1992, where he participated in setting up the Micro Fabrication Center and in establishing the Micromachines Laboratory. Since 2004, he has been a professor in the Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, developing a microelectromechanical systems (MEMS)/bio-MEMS program. His research interests include the science and technology of microsystems, in particular, microscale fluid mechanics and heat transfer. Currently, his main research interest is the development of microfluidic systems for bio/chemical/medical applications. Dr. Zohar is a Fellow of the America Society of Mechanical Engineers (ASME). He is an editor of the Journal of Microelectromechanical Systems, and served as the Cochair of the 21st IEEE International Conference on Microelectromechanical Systems, Tucson, AZ, January 13–17, 2008.

Selected Publications

Chapters

  • Zohar, Y., Lee, L. M., & Cheung, L. S. (2006). Microfluidics: Device Science and Technology. In Microsystems Mechanical Design. Springer, Vienna. doi:10.1007/978-3-211-48549-1_8
  • Zohar, Y. (2001). Microchannel Heat Sinks. In The CRC Handbook of MEMS. doi:10.1201/9781420050905.ch32

Journals/Publications

  • Jiang, L., Khawaja, H., Tahsin, S., Clarkson, T., Miranti, C., & Zohar, Y. (2024). Microfluidic-based human prostate cancer on chip.. Frontiers in Bioengineering and Biotechnology, 1-15.
  • Tahsin, S. K., Jiang, L., Sane, N., Szewczyk, K., Khawaja, H., Zohar, Y., & Miranti, C. K. (2023). Abstract A073: Human prostate-on-chip models to define stromal and epithelial interactions in normal and cancerous prostate. Cancer Research, 83(11_Supplement), A073-A073. doi:10.1158/1538-7445.prca2023-a073
  • Tello, J. A., Jiang, L., Zohar, Y., & Restifo, L. L. (2023). Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery. Neural Dev. doi:10.1186/s13064-023-00174-y
  • Zohar, Y., Restifo, L. L., Jiang, L., & Tello, J. A. (2023). Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery. Neural Development, 18. doi:10.1186/s13064-023-00174-y
  • Zohar, Y., Schroeder, J. A., Jiang, L., & Frankman, Z. D. (2022). Application of Microfluidic Systems for Breast Cancer Research.. Micromachines, 13(2), 152. doi:10.3390/mi13020152
  • Jiang, L., Liu, B. C., Wang, X., Xu, J., Yao, G., & Zohar, Y. (2021). Extracellular Fluid Flow Induces Shallow Quiescence through Physical and Biochemical Cues. Front. Cell Dev. Biol. doi:10.3389/fcell.2022.792719
  • Zohar, Y. (2020). Pharmacokinetic analysis of epithelial/endothelial cell barriers in microfluidic bilayer devices with an air-liquid interface. Micromachines, 11(536). doi:10.3390/mi11050536
  • Zohar, Y., Jiang, L., & Frost, T. S. (2020). Pharmacokinetic Analysis of Epithelial/Endothelial Cell Barriers in Microfluidic Bilayer Devices with an Air–Liquid Interface. Micromachines. doi:10.3390/mi11050536
  • Luo, H., Zhao, C., Song, K., Liu, D., Ma, W., Yu, X., Su, H., Zhang, Z., Zohar, Y., & Lee, Y. (2019). A nonlinear two-degree-of-freedom mass-damper-spring model to predict the isolation of circulating tumor cells in microfluidic-elasto-filtration devices. MICROFLUIDICS AND NANOFLUIDICS, 23(5).
  • Zohar, Y., Jiang, L., Estrada, V., & Frost, T. S. (2019). Convection–diffusion molecular transport in a microfluidic bilayer device with a porous membrane. Microfluidics and Nanofluidics. doi:10.1007/s10404-019-2283-1
  • Zohar, Y., Lee, Y. C., Zhang, Z., Su, H., Yu, X., Ma, W., Liu, D., Song, K., Zhao, C., & Luo, H. (2019). A nonlinear two-degree-of-freedom mass–damper–spring model to predict the isolation of circulating tumor cells in microfluidic-elasto-filtration devices. Microfluidics and Nanofluidics. doi:10.1007/s10404-019-2240-z
  • Zohar, Y., Lynch, R. M., Jiang, L., & Frost, T. S. (2019). Permeability of Epithelial/Endothelial Barriers in Transwells and Microfluidic Bilayer Devices. Micromachines. doi:10.3390/mi10080533
  • Zohar, Y., Miranti, C. K., Tran, M., Tahsin, S., Ivich, F., Jiang, L., & Frank, S. B. (2019). Human stroma and epithelium co-culture in a microfluidic model of a human prostate gland. Biomicrofluidics, 13(6), 064116. doi:10.1063/1.5126714
  • Kim, S., Hinkel, C. J., Coffey, D. S., Zohar, Y., Lee, B., & Gretzer, M. (2018). PD21-06 FLUID DYNAMICS AND MORPHOLOGY IN THE OBSTRUCTED URETHRA. Journal of Urology. doi:10.1016/j.juro.2018.02.1161
  • Luo, H., Chao, Z., Cai, Y., Deng, Y., Zhang, R., Pan, Z., Zohar, Y., & Lee, Y. (2018). The Surface Hydrophobicity Effect on the Capture Efficiency of Cancer Cells in Microfluidic-Elasto-Filtration Chips. Microfluid Nanofluid. doi:10.1007/s10404-019-2240-z

Proceedings Publications

  • Zohar, Y. (2018, December). Application of a microfluidic-based model of a human prostate gland for cancer research. In 12th International Conference on Nano/Molecular Medicine and Engineering, 109-112.
  • Zohar, Y. (2018, December). Characterizing A549 cell line as an epithelial cell monolayer model for pharmacokinetic applications. In 12th International Conference on Nano/Molecular Medicine and Engineering, 27-30.
  • Zohar, Y. (2018, June). Characterizing steady molecular transport between a microchannel pair separated by a porous membrane. In 2018 Synthetic Biology: Engineering, Evolution & Design (SEED), 51.
  • Zohar, Y. (2018, November). Development of a microfluidic-based model of a human prostate gland. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, 1625-1627.
  • Zohar, Y. (2018, November). Protein transport through a separation membrane in a microfluidic device. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, 1976-1978.
  • Zohar, Y., Miranti, C. K., Frank, S. B., Tran, M., Ivich, F., & Jiang, L. (2018). Development of a microfluidic-based model of a human prostate gland. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences.
  • Zohar, Y. (2017, June 2017). The capillary number effect on cell viability in microfluidic elasto-filtration devices for viable circulating tumor cell isolation. In 19th International Conference on Solid-State Sensors, Actuators and Microsystems, 488-491.
  • Hu, L., Jeong, S. Y., Lee, Y., Lee, J., Song, K., Su, H., Yu, X., Zhang, Z., Zhao, C., & Zohar, Y. (2016). Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells. In 2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS), 346-349.
  • Lee, Y., Liang, C., Liu, D., Ma, S., Song, K., Tang, C., Xu, R., Zhao, C., & Zohar, Y. (2015). The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips. In 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 2015, 459-462.
  • Ma, W., Zeng, R., Liu, D., Zohar, Y., & Lee, Y. K. (2014, April 13-16). SOI Technology-based Microfiltration System for Circulating Tumor Cells Isolatio and Enumeration. In 9th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, 333-336.
  • Jiang, L., Cheung, L. S., Gudipaty, T., Stamm, M. T., & Zohar, Y. (2009). Cluster Dynamics in Flow of Suspended Particles in Microchannels. In 2009 IEEE 22nd International Conference on Micro Electro Mechanical Systems, 379-382.
  • Cheung, L. S., Zheng, X., Stopa, A., Schroeder, J. A., Heimark, R. L., Baygents, J. C., Guzman, R. Z., & Zohar, Y. (2008). ATTACHMENT & DETACHMENT OF PROSTATE CANCER CELLS IN A MICROFLUIDIC SYSTEM. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences.
  • Gudipaty, T., Cheung, L. S., Jiang, L., & Zohar, Y. (2008). CLUSTER FORMATION AND EVOLUTION IN PARTICLE-LADEN MICROCHANNEL FLOW. In First Sensor, Signal and Information (SenSIP) Workshop.
  • Jiang, L., Cheung, L. S., Gudipaty, T., & Zohar, Y. (2008).Cluster Formation and Growth in Flow of Dilute Particle Suspension in Microchannels. In Volume 4: Fatigue and Fracture; Fluids Engineering; Heat Transfer; Mechatronics; Micro and Nano Technology; Optical Engineering; Robotics; Systems Engineering; Industrial Applications, 357-362.
  • Chan, Y. C., Lee, Y., Lee, Y., Wong, M., Zohar, Y., & Chan, Y. C. (2005). Effect of sub-micron pillar array on DNA kinetics in a free-solution capillary electrophoresis microsystem. In Ninth International Conference on Miniaturized Systems for Chemistry and Life Sciences.

Poster Presentations

  • Zohar, Y. (2017, November 2017). Characterizing diffusion in a microfluidic system for lung-on-a-chip applications. Junior Investigator Poster Forum. Tucson, AZ, USA: UA College of Medicine.
  • Zohar, Y. (2017, November 2017). Development of a microfluidic model of a human prostate gland for Cancer Research. Junior Investigator Poster Forum. Tucson, AZ, USA: UA College of Medicine.
  • Zohar, Y. (2017, October 2017). A microfluidic-based model of a human prostate gland. UACC Scientific Symposium & Retreat. Phoenix, AZ, USA: UA Cancer Center.

Presentations

  • Zohar, Y. (2014, February 17). Guiding Signals in Life Sciences: Cancer Metatasis. Seminar. University of Arizona, Tucson, AZ: Cancer Biology Program.
  • Zohar, Y. (2014, January 29). Micro/Nanotechnology for Applications in Life Sciences. Seminar. University of Arizona, Tucson, AZ: College of Pharmacy.
  • Zohar, Y. (2014, November 17). Micro/Nanotechnology for Cancer Metastasis Research. Seminar. University of Arizona, Tucson, AZ: Arizona Cancer Center: Cancer Biology Research Conference.

Awards

  • Excellence at the Student Interface
    • UA College of Engineering, Spring 2017